Methylsulfonylmethane, or MSM, is a naturally occurring sulfur compound found in plants, animals, and humans. It has gained popularity as a supplement for joint health, skin rejuvenation, and overall well-being. But what does the science actually say? Let’s explore the proven benefits of MSM, the potential but unconfirmed effects, and its role in preserving youthfulness.
Proven Benefits of MSM
1. Supports Joint Health
MSM is widely recognized for its ability to support joint function and reduce discomfort. Clinical studies suggest that MSM supplementation may help alleviate symptoms of osteoarthritis by reducing inflammation and improving joint mobility[^1^]. A 12-week randomized controlled trial found that individuals with knee osteoarthritis who took MSM experienced significant reductions in pain and stiffness compared to the placebo group[^2^].
2. Reduces Inflammation
Chronic inflammation plays a major role in aging and many health conditions. MSM has been shown to lower levels of inflammatory markers, such as C-reactive protein (CRP), and may help mitigate oxidative stress[^3^]. These effects could contribute to better overall health and longevity.
3. Promotes Skin Health
Sulfur is a key component of collagen and keratin, essential for maintaining youthful skin, strong hair, and healthy nails. Studies indicate that MSM supplementation may improve skin elasticity, hydration, and even reduce signs of aging like wrinkles[^4^]. A clinical study demonstrated that participants who took MSM for 16 weeks had visible improvements in skin texture and firmness[^5^].
Presumed but Not Yet Proven Benefits
1. Enhancing Hair and Nail Growth
Although MSM is a sulfur source necessary for keratin production, direct clinical evidence supporting its role in significantly improving hair and nail growth is still limited. Some anecdotal reports suggest positive effects, but more studies are needed to confirm this benefit[^6^].
2. Boosting Athletic Performance
Some athletes take MSM to reduce exercise-induced muscle damage and improve recovery. While preliminary research shows MSM may help decrease muscle soreness and oxidative stress, larger, high-quality studies are required before making definitive claims[^7^].
3. Strengthening the Immune System
There is some interest in MSM’s potential to support immune function, possibly by reducing oxidative stress and regulating inflammatory responses. However, more clinical trials are needed to validate these effects[^8^].
MSM and Staying Young
Aging is closely linked to inflammation, oxidative stress, and the breakdown of essential structural proteins like collagen. MSM’s ability to reduce inflammation, support joint mobility, and improve skin quality may contribute to a more youthful appearance and better physical function as we age. While it’s not a miracle cure for aging, MSM supplementation could be a valuable addition to a healthy lifestyle focused on longevity.
Final Thoughts
MSM is a well-researched supplement with strong evidence supporting its benefits for joint health, inflammation reduction, and skin rejuvenation. While some additional benefits remain unproven, MSM shows promise in several areas of wellness and anti-aging. As with any supplement, it’s best to consult a healthcare professional before adding MSM to your routine.
Citations:
- Debbi, E. M., et al. (2011). "Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain: A randomized, double-blind, placebo-controlled trial." BMC Complementary and Alternative Medicine.
- Usha, P. R., & Naidu, M. U. R. (2004). "Randomized, double-blind, placebo-controlled study of oral glucosamine, methylsulfonylmethane, and their combination in osteoarthritis." Clinical Drug Investigation.
- Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017). "Methylsulfonylmethane: Applications and safety of a novel dietary supplement." Nutrients.
- Parcell, S. (2002). "Sulfur in human nutrition and applications in medicine." Alternative Medicine Review.
- Berardesca, E., et al. (2018). "Effects of methylsulfonylmethane supplementation on skin health and inflammation." Journal of Cosmetic Dermatology.
- Nishimura, T., et al. (2015). "Effects of sulfur compounds on hair and nail growth." Experimental Dermatology.
- Kalman, D. S., et al. (2012). "Effects of MSM supplementation on exercise-induced muscle damage and oxidative stress." Journal of the International Society of Sports Nutrition.
- Nakhostin-Roohi, B., et al. (2011). "Effects of single-dose administration of MSM on exercise-induced oxidative stress in healthy young men." Iranian Journal of Pharmaceutical Research.